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SAG dihydrochloride

Based on 79 reference(s) in Google Scholar 8 10 79

Axon 4392

CAS [2702366-44-5]

MF C28H28ClN3OS·2HCl
MW 562.98

  • Purity: 99%
  • Soluble in water, DMSO and EtOH
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SAG dihydrochloride

Description

SAG dihydrochloride is a Smo agonist with an apparent Kd value of 59 nM (SAG/Smo complex) and an EC50 value of 3 nM (pathway activation in a mouse cultured cell assay, Shh-LIGHT2). SAG binds to the Smo heptahelical bundle in a manner that antagonizes cyclopamine action.

KEYWORDS: SAG dihydrochloride | Supplier | SMO agonist | CAS [912545-86-9] | CAS [2702366-44-5] | CAS [2095432-58-7 ] | Cyclopamine | Smoothened (SMO) | Agonist | Receptors | Tumorigenesis

Smoothened (SMO) agonist

Chemical name

N-(trans-4-(Methylamino)cyclohexyl)-N-((3-(4-pyridyl)phenyl)methyl)-3-chloro-1-benzothiophene-2-carboxamide dihydrochloride

Parent CAS No.

[912545-86-9]

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Size Unit Price Stock
5 mg €110.00 In Stock
25 mg €330.00 In Stock
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2 x 5 mg €180.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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