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Axon 4390
CAS [1243244-14-5]
MF C23H20N6OMW 396.45
LGK974 is a potent and highly specific PORCN inhibitor with IC50 values of 1 nM (PORCN radioligand binding assay) and 0.4 nM (Wnt coculture assay). LGK974 potently inhibits Wnt signaling in vitro and in vivo, including reduction of the Wnt-dependent LRP6 phosphorylation and the expression of Wnt target genes, such as AXIN2.
KEYWORDS: LGK974 | Supplier | PORCN inhibitor | WNT974 | LGK 974 | LGK-974 | WNT 974 | WNT-974 | CAS [1243244-14-5] | Wnt proteins | Porcupine | Inhibitor | Enzymes | Wnt-driven cancer
N-(5-(2-Pyrazinyl)-2-pyridyl)(2',3-dimethyl-2,4'-bipyridyl-5-yl)acetamide
[1243244-14-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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