Pifithrin-μ is an inhibitor of p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation. Pifithrin-μ is also an inhibitor of inducible heat shock protein 70 and interacts selectively with HSP70 and leads to a disruption of the association between HSP70 and several of its cochaperones and substrate proteins.

KEYWORDS: Pifithrin-μ | Supplier | p53/HSP70 inhibitor | PFTμ | Pifithrinμ | Pifithrin μ | PAS | PFT μ | PFT-μ | PFTmu | PAS | CAS [64984-31-2] | Unfolded Protein Response (Non Selective) | p53 | Hsp70 | Inhibitor | Transcription Factors | Enzymes | Lymphomagenesis