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VVD-214 - RO7589831

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 4271

CAS [3026500-20-6]

MF C20H21F2N3O4S
MW 437.46

  • Purity: 98%
  • Soluble in DMSO

VVD-214

Description

VVD214 is a potent, selective, allosteric inhibitor of WRN helicase (Werner syndrome ATP-dependent helicase). It covalently engages cysteine 727 of WRN in a nucleotide cooperative manner and inhibits ATP hydrolysis and helicase activity.

KEYWORDS: VVD-214 | Supplier | WRN helicase inhibitor | RO7589831 | VVD214 | VVD 214 | RO-7589831 | RO 7589831 | CT-VVD214 | CAS [3026500-20-6] | DNA-RNA | Helicase-Primase | Inhibitor | Enzymes

Potent, selective, allosteric inhibitor of WRN helicase

Chemical name

(S,E)-N-(1-Cyclopropyl-3-(methylsulfonyl)allyl)-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[3026500-20-6]

Related Products

Axon ID Name Description From price
4214 HRO761 Potent, selective, orally active and allosteric WRN inhibitor €140.00

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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