ABBV-467

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 4263

CAS [2287186-66-5]

MF C53H51Cl2FN6O9S
MW 1037.98

  • Purity: 98%
  • Optical purity: 98
  • Soluble in DMSO
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ABBV-467

Description

ABBV-467 is a highly potent and selective MCL-1 inhibitor (Ki < 0.01nM). ABBV-467 induces tumor regression in xenograft models of MM and AML when combined with Venetoclax (Axon 2141).

KEYWORDS: ABBV-467 | Supplier | MCL-1 inhibitor | ABBV467 | ABBV 467 | CT-ABBV467 | CAS [2287186-66-5] | Non Selective | Mcl-1 | Inhibitor | Proteins

Potent and selective MCL-1 inhibitor

Chemical name

(11R,20R)-23,26-dichloro-14-[[2-[4-[[(2S)-1,4-dioxan-2-yl]methoxy]phenyl]pyrimidin-4-yl]methoxy]-3-(4-fluorophenyl)-24,25-dimethyl-20-[(4-methylpiperazin-1-yl)methyl]-10,18,21-trioxa-4-thia-6,8-diazapentacyclo[20.2.2.12,5.113,17.09,28]octacosa-1(25),2,5,7

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[2287186-66-5]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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