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Axon 4245
CAS [2929304-05-0]
MF C35H39N5O5MW 609.72
UNC8732 is a second-generation NSD2 degrader (DC50 value of 60 nM; Dmax of 97%) that demonstrates improved NSD2 degradation and H3K36me2 reduction in cells. UNC8732 contains a primary alkyl amine, which is metabolized in cells to an active aldehyde species that promotes NSD2 degradation through the recruitment of FBXO22, a substrate recognition subunit of a Cullin 1 E3 ligase complex.
KEYWORDS: UNC8732 | Supplier | NSD2 degrader | UNC 8732 | UNC-8732 | CAS [2929304-05-0] | [2929304-06-1] | Histone | HMTase | Inhibitor | Enzymes | FBXO22 | Cullin 1 E3 ligase complex | Targeted protein degradation | TPD | Histone methyltransferase
N-(4-(2-(6-Aminohexanoyl)-1,2,3,4-tetrahydroisoquinolin-6-ylcarbamoyl)benzyl)-N-cyclopropyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
[2929304-05-0]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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