UNC8732

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 4245

CAS [2929304-05-0]

MF C35H39N5O5
MW 609.72

  • Purity: 98%
  • Soluble in 0.1N HCl(aq), DMSO and EtOH
Recently added

UNC8732

Description

UNC8732 is a second-generation NSD2 degrader (DC50 value of 60 nM; Dmax of 97%) that demonstrates improved NSD2 degradation and H3K36me2 reduction in cells. UNC8732 contains a primary alkyl amine, which is metabolized in cells to an active aldehyde species that promotes NSD2 degradation through the recruitment of FBXO22, a substrate recognition subunit of a Cullin 1 E3 ligase complex.

KEYWORDS: UNC8732 | Supplier | NSD2 degrader | UNC 8732 | UNC-8732 | CAS [2929304-05-0] | [2929304-06-1] | Histone | HMTase | Inhibitor | Enzymes | FBXO22 | Cullin 1 E3 ligase complex | Targeted protein degradation | TPD | Histone methyltransferase

Highly potent second-generation NSD2 degrader

Chemical name

N-(4-(2-(6-Aminohexanoyl)-1,2,3,4-tetrahydroisoquinolin-6-ylcarbamoyl)benzyl)-N-cyclopropyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

Parent CAS No.

[2929304-05-0]

Order
Size Unit Price Stock
5 mg €210.00 In Stock
25 mg €790.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €350.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...