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BMS-986365 - CC-94676

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 4232

CAS [2446928-30-7]

MF C41H45F3N8O5S
MW 818.91

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO and EtOH

BMS-986365

Description

BMS-986365 is a highly potent and selective androgen receptor (AR) degrader that induces rapid and deep degradation of both wildtype and mutant forms of the receptor residing in either the cytoplasmic or nuclear compartments of the cell. Moreover, BMS-986365 is a ligand-directed degrader (LDD) that enables the CRL4CRBN E3 ligase-dependent ubiquitination and degradation of AR (DC50 10 to 40 nM, Ymin 7 to 19%).

KEYWORDS: BMS-986365 | Supplier | AR degrader | CC-94676 | BMS986365 | BMS 986365 | CC94676 | CC 94676 | CAS [2446928-30-7] | Androgenic hormones | Androgen (AR) | Degrader | Receptors | Advanced prostate cancer

Highly potent and selective androgen receptor (AR) degrader

Chemical name

2-((R)-4-(2-(4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-ethylphenoxy)ethyl)-2-methylpiperazin-1-yl)-N-(3-(2,6-dioxopiperidin-3-ylamino)phenyl)acetamide

Parent CAS No.

[2446928-30-7]

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Size Unit Price Stock
5 mg €150.00 In Stock
25 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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