Carfilzomib - PR-171

Based on 1839 reference(s) in Google Scholar 8 10 1839

Axon 4218

CAS [868540-17-4]

MF C40H57N5O7
MW 719.91

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO
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An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.

KEYWORDS: Carfilzomib | Supplier | Proteasome inhibitor | PR-171 | PR171 | PR 171 | CT-CARF | CAS [868540-17-4] | Non Selective (Ubiquitin peptides) | Inhibitor

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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