Birinapant is a cell permeable, orally bioavailable, synthetic bivalent small molecule peptido mimetics of second mitochondrial-derived activator of caspases (SMAC) and potent and selective inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with Kd values of 45 nM and <1 nM for XIAP and cIAP1, respectively. SMAC mimetics Birinapant and LCL-161 (Axon 3902) are also negative regulators of HIV-1 transcription, promoting reversal of viral latency.

Keywords: Birinapant | Supplier | Bivalent Smac mimetic and potent antagonist for XIAP and cIAP1 inhibitor | TL32711 | TL-32711 | TL 32711 | CT-BIRI | CAS [1260251-31-7] | Caspase | IAP | Inhibitor | Proteins