IPI-549 is a potent and isoform Gamma (γ ) selective phosphoinositide-3-kinase (PI3Kγ) Inhibitor (Kd = 0.29 nM), with biochemcial IC50 (nM) for PI3K isoforms: 3200 (α), 3500 (β), 16 (γ), and >8400 (δ), respectively and Cellular IC50 (nM) for PI3K isoforms: 250 (α), 240 (β), 1.2 (γ) and 180 (δ) respectively. It shows no significant inhibition for a panel of 468 mutant and non mutant protein and lipid kinases (including Class II PI3K isoforms) at 1 µM. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo.

Keywords: IPI-549 | Supplier | PI3Kγ inhibitor | Eganelisib | IPI549 | IPI 549 | CT-IPI549 | CAS [1693758-51-8] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes