LY2606368 mesylate - Prexasertib mesylate

Based on 112 reference(s) in Google Scholar 8 10 112

Axon 4145

CAS [1234015-55-4]

MF C18H19N7O2.CH4O3S
MW 461.49

  • Purity: 99%
  • Soluble in DMSO
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LY2606368 mesylate

Description

LY2606368 is a potent and selective ATP competitive inhibitor of the CHK protein kinase. It preferentially acts on CHK1 (with a biochemical Ki of 0.9 nM) over CHK2 and RSK (with Ki of 8 nM and 9 nM, respectively). CHK1 is a protein kinase that regulates the tumor cell’s response to DNA damage often caused by treatment with chemotherapy. In response to DNA damage, CHK1 blocks cell cycle progression in order to allow to repair damaged DNA, thereby limiting the efficacy of chemotherapeutic agents. Inhibiting CHK1 in combination with chemotherapy can enhance tumor cell death by preventing these cells from recovering from DNA damage.

Keywords: LY2606368 mesylate | Supplier | CHK1 inhibitor | Prexasertib mesylate | LY-2606368 | LY 2606368 | CT-LY260M | CAS [1234015-55-4] | [1234015-52-1] | DNA-RNA | CHK | Inhibitor | Enzymes

Potent and selective ATP competitive inhibitor of the CHK protein kinase

Chemical name

5-(5-(2-(3-Aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile methanesulfonate

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1234015-52-1]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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