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MG degrader compound E14

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 4143

CAS [N.A.]

MF C31H37N5O7
MW 591.66

  • Purity: 98%
  • Soluble in DMSO and EtOH
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MG degrader compound E14

Description

MG degrader compound E14 is a potent molecular glue (MG) degrader targeting IKZF1/3, GSPT1 and 2 with profound effects on a panel of cancer cells (EC50 values of 11.08 nM and 1.485 nM in MM.1S and NCI-H929 cells, respectively).

KEYWORDS: MG degrader compound E14 | Supplier | MG degrader | E 14 | E-14 | CAS [N.A.] | Protein degradation | Ubiquitin Ligase (E3; other) | Degrader | Enzymes | Molecular glue | Cereblon E3 ligase | CRBN | PROTAC

Potent molecular glue degrader targeting IKZF1/3, GSPT1 and 2

Chemical name

N-(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-ylamino)butyl)-2-(N-isobutylformamido)-2-(3-methoxyphenyl)acetamide

Parent CAS No.

[N.A.]

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5 mg €130.00 In Stock
25 mg €460.00 In Stock
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2 x 5 mg €220.00 In Stock
2 x 25 mg €760.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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