Based on 44 reference(s) in Google Scholar 8 10 44

Axon 4140

CAS [1821428-35-6]

MF C26H31N5O3
MW 461.56

  • Purity: 99%
  • Soluble in DMSO
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ATMK (Ataxia Telangiectasia Mutated Kinase), a serine/threonine protein kinase, is upregulated in a variety of cancer cell types, and activated in response to DNA damage and plays a key role in DNA-strand repair. AZD0156 is an orally bioavailable small molecule inhibiting the kinase activity of ATM and ATM-mediated signaling, preventing DNA damage checkpoint activation, disrupting DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. In addition, AZD0156 also sensitizes tumor cells to chemo- and radiotherapy.

Keywords: AZD0156 | Supplier | ATM inhibitor | AZD-0156 | AZD 0156 | CT-A0156 | CAS [1821428-35-6] | DNA-RNA | ATM | Inhibitor | Enzymes

Selective and orally active ATM inhibitor

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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