AZD5582 dihydrochloride

Based on 38 reference(s) in Google Scholar 8 10 38

Axon 4139

CAS [1883545-51-4]

MF C58H78N8O8.2HCl
MW 1088.21

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO
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AZD5582 dihydrochloride

Description

AZD5582 dihydrochloride is a cell permeable, novel class of dimeric SMAC mimetic designed to mimick the AVPI motif of SMAC. It is a potent and selective inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein with IC50 values of 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2, respectively. At nanomolar concentrations AZD5582 causes extensive degradation of cIAP-1 and cIAP-2, and induces apoptosis in MDA-MB-231 breast cancer cells. It causes substantial tumor regressions following two weekly doses of 3.0 mg/kg in MDA-MB-231 xenograft-bearing mice.

Keywords: AZD5582 dihydrochloride | Supplier | Apoptosis proteins (IAPs) inhibitor | AZD-5582 | AZD 5582 | CT-A5582 | CAS [1258392-53-8] - [1883545-51-4] | Caspase | IAP | Inhibitor | Proteins

Apoptosis proteins (IAPs) inhibitor

Chemical name

(S,S,2S,2'S)-N,N'-((1S,1'S,2R,2'R)-2,2'-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) dihydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1258392-53-8]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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