PBF-509 - NIR178 | Taminadenant

Based on 6 reference(s) in Google Scholar 8 10 6

Axon 4132

CAS [1337962-47-6]

MF C10H8BrN7
MW 306.12

  • Purity: 99%
  • Soluble in DMSO



PBF-509 an oral immunotherapy agent, is a potent and selective A2A (Adenosine 2A) receptor antagonist, binding to human A2A receptor with a Ki value of 12 nM. It inhibits A2AR expressed on T lymphocytes, thus abrogates the adenosine/ A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. It is also reported as a potential pro-dopaminergic drug for Parkinson’s disease (PD) management.

Keywords: PBF-509 | Supplier | A2A receptor antagonist | NIR178 | Taminadenant | PBF509 | PBF 509 | NIR-178 | NIR 178 | CT-PBF509 | CAS [1337962-47-6] | Adenosine | A2A | Antagonist | Receptors

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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