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GNE-781

Based on 7 reference(s) in Google Scholar 8 10 7

Axon 4127

CAS [1936422-33-1]

MF C27H33F2N7O2
MW 525.59

  • Purity: 99%
  • Soluble in DMSO and EtOH

GNE-781

Description

GNE-781 is a highly potent, selective, and orally bioavailable CBP inhibitor with IC50 values of 0.94 nM, 6.2 nM and 5.1 μM for CBP, CBP BRET and BRD4(1), respectively. GNE-781 displays antitumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner.

Keywords: GNE-781 | Supplier | CBP inhibitor | GNE781 | GNE 781 | CAS [1936422-33-1] | Histone | HAT | Inhibitor | Enzymes | Cancer immunotherapy | Non-CNS penetrant

Highly potent, selective, and orally bioavailable CBP inhibitor

Chemical name

3-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide

Parent CAS No.

[1936422-33-1]

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Size Unit Price Stock
5 mg €160.00 In Stock
25 mg €640.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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