(±)-trans-ML-SI3

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 4114

CAS [2108567-79-7]

MF C23H31N3O3S
MW 429.58

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

(±)-trans-ML-SI3

Description

(±)-trans-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50 values of 3.1 and 28.5 µM, respectively) and an activator of TRPML2 (EC50 value of 3.3 µM.

C Leser et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;0(0):112966.

W Wang et al. Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1373-81.

CNS TRPML

TRPML1/3 inhibitor and TRPML2 activator

Chemical name

rel-N-((1R,2R)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide

Parent CAS No.

[2108567-79-7]

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