DFPQ is a potent and selective β-arrestin-biased negative allosteric modulator (NAM) for the β2-adrenergic receptor. DFPQ selectively inhibits β-arrestin interaction with the β2AR without affecting β-agonist-promoted cAMP production. DFPQ attenuates functional desensitization of the β2AR in airway smooth muscle, augmenting the ability of β-agonists to sustain bronchorelaxation and inhibition of cell migration under conditions of chronic β-agonist treatment.

KEYWORDS: DFPQ | Supplier | β2 NAM | AP-06-202 | AP 06-202 | AP06-202 | CAS [911678-60-9] | (Nor-)Adrenaline | Adrenoceptor β2 | NAM | Receptors | Asthma | Airway disease