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Axon 4078
CAS [2935957-44-9]
MF C24H26FN5O3MW 451.49
HMC-H8 is a potent and highly selective HPK1 inhibitor with an IC50 value of 1.11 nM. HMC-H8 exhibited robust inhibition of p-SLP 76 (IC50 value of 283.0 nM) and promotion IL-2 release (EC50 value of 157.08 nM), and INF-γ production in a dose-dependent manner in vitro assays.
KEYWORDS: HMC-H8 | Supplier | HPK1 inhibitor | HMCH8 | HMC H8 | CAS [2935957-44-9] | MAPK | MAP4K | Inhibitor | Enzymes | T cell receptor signaling | Immune-oncology | Hematopoietic progenitor kinase 1
2-(2-Fluoro-6-methoxyphenyl)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4-carboxamide
[2935957-44-9]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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