Varespladib - LY315920

Based on 127 reference(s) in Google Scholar 8 10 127

Axon 4077

CAS [172732-68-2]

MF C21H20N2O5
MW 380.39

Purity: 99%
Soluble in DMSO

Varespladib

Description

Varespladib is an inhibitor of human and mouse sPLA2 group IIA, V, and X enzymes with IC50 values in the low nM range.

DW Snyder et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.

H Fraser et al. Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice. J Cardiovasc Pharmacol. 2009 Jan;53(1):60-5.

sPLA2 inhibitor

Chemical name

2-(3-(2-Amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yloxy)acetic acid

Source information

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Parent CAS No.

[172732-68-2]

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2661	AZD2716	Potent secreted phospholipase A2 (sPLA2) inhibitor	€145.00
4032	Varespladib methyl	Secretory phospholipase A2 (sPLA2) inhibitor	Inquire

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