Doxorubicin hydrochloride - Adriamycin hydrochloride

Based on 88000 reference(s) in Google Scholar 8 10 88000

Axon 4072

CAS [25316-40-9]

MF C27H29NO11.HCl
MW 579.98

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water

Doxorubicin hydrochloride


Doxorubicin hydrochloride is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

Keywords: Doxorubicin hydrochloride | Supplier | Cytotoxic anthracycline antibiotic | Adriamycin hydrochloride | CT-DOXO | CAS [25316-40-9] | [23214-92-8] | DNA-RNA | TOPO | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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