AZD4635 - HTL-1071 | Imaradenant

Based on 12 reference(s) in Google Scholar 8 10 12

Axon 4069

CAS [1321514-06-0]

MF C15H11ClFN5
MW 315.73

  • Purity: 99%
  • Soluble in DMSO



AZD4635 is an orally bioavailable, potent and selective A2A (Adenosine 2A) receptor antagonist, binding to human A2A receptor with a Ki value of 1.7 nM, and with > 30-fold selectivity over other adenosine receptors. High adenosine level in tumors, produced by stimulating A2A receptors, is immune suppressive, which prevents T-cells within the immune system from being activated thus reduces their ability to destroy cancer cells. Antagonizing A2A receptors can therefore promote the anti-cancer response of T-cells within the tumour microenvironment.

Keywords: AZD4635 | Supplier | A2A antagonist | HTL-1071 | Imaradenant | AZD-4635 | AZD 4635 | HTL1071 | HTL 1071 | CT-A4635 | CAS [1321514-06-0] | Adenosine | A2A | Antagonist | Receptors

Potent and selective adenosine A2A antagonist

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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