AZD7648 is an orally available potent and selective next generation DNA-dependent protein kinase (DNA-PK) inhibitor (Enzymatic and Cellular IC50s = 0.6 nM, 91 nM, respectively ), highly selective against a panel of 397 other kinases, including closely-related Kinases such as ATM, ATR, and PI3Kα, β, δ, γ. Exhibits antitumor efficacy either as a monotherapy or in combination with either cytotoxic chemotherapies or novel Anti-Cancer agents.

Keywords: AZD7648 | Supplier | DNA-PK inhibitor | AZD-7648 | AZD 7648 | CT-A7648 | CAS [2230820-11-6] | DNA-RNA | DNA-PK | Inhibitor | Enzymes