Atrasentan - A127722 | ABT627

Based on 467 reference(s) in Google Scholar 8 10 467

Axon 4058

CAS [173937-91-2]

MF C29H38N2O6
MW 510.62

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO and EtOH

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Atrasentan

Description

Atrasentan is a highly potent, selective, and orally active ETA-selective endothelin receptor antagonist with an IC50 value of 0.055 nM.

Keywords: Atrasentan | Supplier | ETA antagonist | A127722 | ABT627 | A 127722 | A-127722 | ABT 627 | ABT-627 | CAS [173937-91-2] | Endothelin | ETA | Antagonist | Receptors

M Winn et al. 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. J Med Chem. 1996 Mar 1;39(5):1039-48.

TJ Opgenorth et al. Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist. J Pharmacol Exp Ther. 1996 Feb;276(2):473-81.

JL Wessale et al. Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies. Clin Sci (Lond). 2002 Aug;103 Suppl 48:112S-117S.

Highly potent, selective, and orally active endothelin-A (ETA) antagonist

Chemical name

(2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid

Parent CAS No.

[173937-91-2]

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Atrasentan - A127722 | ABT627

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Atrasentan - A127722 | ABT627

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