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CEP-37440 hydrochloride

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 4038

CAS [N.A.]

MF C30H38ClN7O3.HCl
MW 616.58

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in 0.1N HCl(aq) and DMSO

CEP-37440 hydrochloride

Description

CEP-37440 is a highly potent, selective and orally active inhibitor of ALK (Ezymatic IC50: 3.5 nM , Cellular IC50: 40 nM , Cellular IC50 in 75% human plasma: 120 nM) and FAK (Ezymatic IC50: 2.3 nM , Cellular IC50: 88 nM ), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK /FAK mediated human cancer cells and tumor xenograft models in mice.

KEYWORDS: CEP-37440 hydrochloride | Supplier | ALK and FAK inhibitor | CEP37440 | CEP 37440 | Phosphatidylinositol | Akt | FAK | Inhibitor | Enzymes

Potent, selective and orally active inhibitor of ALK anf FAK

Chemical name

(S)-2-(5-Chloro-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ylamino)pyrimidin-4-ylamino)-N-methylbenzamide hydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1391712-60-9]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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