RG7388 is an orally active, potent and selective inhibitor of the P53-MDM2 interaction with Ki at low nM.  It binds to the MDM2 protein with a higher potency and selectivity, and has substantially improved pharmacological properties and superior clinical efficacy at lower dose. It is a second generation P53-MDM2 inhibitor under clinical investigation.

KEYWORDS: RG-7388 | Supplier | MDM2 antagonist | Idasanutlin | RO5503781 | RG7388 | RG 7388 | RO-5503781 | RO 5503781 | CT-RG7388 | CAS [1229705-06-9] | p53 | HDM-MDM | Antagonist | Enzymes