XL-147 is a potent, selective and orally bioavailable ATP-competitive small molecule inhibitor targeting pan-class I phosphatidylinositol 3 kinase (PI3K) family with IC50 values of 39, 383, 36 and 23 nM for p110 α, β, δ and γ isoforms, and is highly selective over mTOR (IC50 > 15000 nM), VPS34 (IC50 = 6975 nM), DNAPK (IC50 = 4750 nM).

KEYWORDS: XL-147 | Supplier | PI3K inhibitor | Pilaralisib | SAR245408 | XL147 | XL 147 | SAR 245408 | SAR-245408 | CT-XL147 | CAS [934526-89-3] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes