NMS-1286937 - Onvansertib | NMS-P 937

Based on 27 reference(s) in Google Scholar 8 10 27

Axon 4007

CAS [1034616-18-6]

MF C24H27F3N8O3
MW 532.52

  • Purity: 99%
  • Soluble in DMSO



NMS1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. NMS-1286937 selectively and effectively inhibits PLK1 (with IC50 at low nM), inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells.

KEYWORDS: NMS-1286937 | Supplier | PLK1 inhibitor | Onvansertib | NMS-P 937 | NMS1286937 | NMS 1286937 | NMS-P-937 | NMS-P-937 | CT-NMS128 | CAS [1034616-18-6] | Non Selective (CHK2;p53) | PLK | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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