GSK2879552 dihydrochloride

Based on 47 reference(s) in Google Scholar 8 10 47

Axon 4005

CAS [1902123-72-1]

MF C23H28N2O2.2HCl
MW 437.40

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

GSK2879552 dihydrochloride


GSK2879552 is a first-in-class, orally bioavailable, potent, selective, and mechanism-based irreversible inhibitor of Lysine specific demethylase 1 (LSD1). LSDI, a histone H3K4me1/2 demethylase found in various transcriptional co-repressor complexes, including Histone Deacetylases (HDAC1/2) and Co-Repressor for Element-1-Silencing Transcription factor (CoREST). Studies have implicated that LSD1 is a key regulator of the epigenome that modulates gene expression through post-translational modification of histones and through its presence in transcriptional complexes, and is overexpressed in certain tumor cells. Inhibition of LSD1 enhances H3K4 methylation and increases the expression of tumor-suppressor genes.

KEYWORDS: GSK2879552 dihydrochloride | Supplier | LSD1 inhibitor | GSK-2879552 | GSK 2879552 | CT-GSK287 | CAS [1902123-72-1] | [1401966-69-5] | Histone | Histone demethylase | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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