MGCD516 - Sitravatinib

Based on 29 reference(s) in Google Scholar 8 10 29

Axon 3998

CAS [1123837-84-2]

MF C33H29F2N5O4S
MW 629.68

  • Purity: 98%
  • Soluble in DMSO

MGCD516

Description

MGCD516 is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

KEYWORDS: MGCD516 | Supplier | RTK inhibitor | Sitravatinib | MGCD516 | MGCD516 | CT-MG516 | CAS [1123837-84-2] | VEGF | Axl | MER | VEGFR | c-KIT | Inhibitor | Receptors

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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