GSK2830371

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 3994

CAS [1404456-53-6]

MF C23H29ClN4O2S
MW 461.02

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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GSK2830371

Description

The serine/threonine phosphatase Wip1 plays an important role in tumor development. Despite its aberrant activity characterizing different forms of cancer, selective inhibitors are still lacking. GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with an IC50 of 6 nM. It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to lack of this domain in other phosphatases, its binding to GSK2830371 results in a selective and potent inhibition of Wip1. When tested in animal models suffering from a blood cancer (lymphoma), GSK2830371 effectively blocked the tumoral growth.

KEYWORDS: GSK2830371 | Supplier | Wip1 phosphatase inhibitor | GSK-2830371 | GSK 2830371 | CT-GSK283 | CAS [1404456-53-6] | Non Selective (Serine-Threonine;Tyrosine Specific Phosphodiesters) | PPM1D | Inhibitor | Enzymes

Highly selective Wip1 phosphatase inhibitor

Chemical name

(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1404456-53-6]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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