Based on 51 reference(s) in Google Scholar 8 10 51

Axon 3972

CAS [1430844-80-6]

MF C38H38N6O3S
MW 658.81

  • Purity: 99%
  • Soluble in DMSO



A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of 600-fold selectivity), BCL-W (Ki = 4 nM, >400-fold selectivity), and MCL-1 (Ki = 142 nM, >14000-fold selectivity)..A-1331852, together with A-1155463 (Axon 3957), represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity.

KEYWORDS: A-1331852 | Supplier | BCL-XL selective inhibitor | A1331852 | A 1331852 | CAS [1430844-80-6] | Non Selective | Bcl | Inhibitor | Proteins

BH3 mimetic Ligand of BCL protein BCL-XL

Chemical name

3-[1-(1-Adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylic acid

Parent CAS No.


Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
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Size Unit Price Stock
2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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