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Axon 3972

CAS [1430844-80-6]

MF C38H38N6O3S
MW 658.81

  • Purity: 99%
  • Soluble in DMSO
Recently added



A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of 600-fold selectivity), BCL-W (Ki = 4 nM, >400-fold selectivity), and MCL-1 (Ki = 142 nM, >14000-fold selectivity). It selectively disrupts BCL-XL–BIM complex and induces the hallmarks of apoptosis in BCL-XL–dependent Molt-4 cells with IC50 values in the low nM range without any measurable effects on MEF cells lacking BAK or BAX. Orally administered A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent. It significantly inhibits tumor growth given ether as a single agent, or combined with docetaxel in seven subcutaneous xenograft models of solid tumors, including breast cancer, NSCLC, and ovarian cancer. A-1331852, together with A-1155463 (Axon 3957), represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity.

KEYWORDS: A-1331852 | Supplier | BCL-XL selective inhibitor | A1331852 | A 1331852 | CT-A133 | CAS [1430844-80-6] | Non Selective | Bcl | Inhibitor | Proteins

BH3 mimetic Ligand of BCL protein BCL-XL

Chemical name

, 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid

Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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