Based on 7 reference(s) in Google Scholar 8 10 7

Axon 3971

CAS [1163719-56-9]

MF C27H24FN7O3
MW 513.52

  • Purity: 99%
  • Soluble in DMSO



CCT196969 is a paradox-breaking pan RAF Inhibitor, targeting simultaneously RAF and SFKs. BRAF and MEK inhibitors are effective in treating BRAF mutant melanoma however most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs. Resistance is often mediated by pathway reactivation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which drive paradoxical reactivation of the pathway. By targeting pan RAF and SFKs, CCT196969 demonstrates efficacious inhibitory activity towards MEK/ERK in BRAF and NRAS mutant melanoma, while showing no effect on paradoxical pathway activation.

KEYWORDS: CCT196969 | Supplier | pan-Raf inhibitor | CCT-196969 | CCT 196969 | CT-CCT196 | CAS [1163719-56-9] | MEK | RAF | Inhibitor | Enzymes

Paradox-breaking pan RAF Inhibitor

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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