Darapladib - SB-480848

Based on 152 reference(s) in Google Scholar 8 10 152

Axon 3968

CAS [356057-34-6]

MF C36H38F4N4O2S
MW 666.77

Purity: 99%
Soluble in DMSO

Darapladib

Description

Darapladib is a selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor.

KEYWORDS: Darapladib | Supplier | Application Flyer | SB-480848 | SB480848 | SB 480848 | CAS [356057-34-6] | (S)-Palmitoylated proteins | APT | Inhibitor | Enzymes

JA Blackie et al. The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70.

MM Hu et al. The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice. Acta Pharmacol Sin. 2011 Oct;32(10):1253-8.

Selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor

Chemical name

N-(2-(Diethylamino)ethyl)-2-(2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)acetamide

Parent CAS No.

[356057-34-6]

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Darapladib - SB-480848

Description

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