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EPZ-5676 - Pinometostat | EPZ-005676

Based on 56 reference(s) in Google Scholar 8 10 56

Axon 3960

CAS [1380288-87-8]

MF C30H42N8O3
MW 562.71

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

EPZ-5676

Description

EPZ-5676 is a potent, selective and S-adenosyl methionine (SAM) competitive inhibitor of DOT1L methyltransferase (Ki = 80 pM), displaying 37,000-fold selectivity over all other methyltransferases tested. It inhibits H3K79 methylation and MLL-fusion target gene expression, and potently and selectively kills acute leukemia cell lines bearing MLL translocations.

KEYWORDS: EPZ-5676 | Supplier | DOT1L histone methyltransferase inhibitor | Pinometostat | EPZ-005676 | EPZ5676 | EP Z5676 | EPZ005676 | EPZ 005676 | CT-EPZ676 | CAS [1380288-87-8] | Histone | HMTase | Inhibitor | Enzymes

Selective and S-adenosyl methionine (SAM) competitive inhibitor of DOT1L methyltransferase

Chemical name

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-tert-butyl-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1380288-87-8]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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