A-1155463 dihydrochloride

Based on 39 reference(s) in Google Scholar 8 10 39

Axon 3957

CAS [N.A.]

MF C35H32FN5O4S2.2HCl
MW 742.71

  • Purity: 99%
  • Soluble in DMSO

A-1155463 dihydrochloride


A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of 7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 (Axon 3972), represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killing BCL-XL–dependent Molt-4 cells (EC50=70nM) without measurable cytotoxicity against BCL-2–dependent RS4, inducing the hallmarks of intrinsic apoptosis.

KEYWORDS: A-1155463 dihydrochloride | Supplier | BCL-XL selective inhibitor | A1155463 | A 1155463 | CT-A115 | CAS [N.A.] | [1235034-55-5] | Non Selective | Bcl | Inhibitor | Proteins

BH3 mimetic Ligand of BCL protein BCL-XL

Chemical name

2-(8-(Benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-ynyl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid dihydrochloride

Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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