Altiratinib - DCC-2701

Based on 11 reference(s) in Google Scholar 8 10 11

Axon 3946

CAS [1345847-93-9]

MF C26H21F3N4O4
MW 510.46

  • Purity: 99%
  • Soluble in DMSO



Altiratinib was designed based on the rationale of engineering a single therapeutic agent able to address multiple hallmarks of cancer. Specifically, Altiratinib inhibits not only mechanisms of tumor initiation and progression, but also drug resistance mechanisms in the tumor and microenvironment through balanced inhibition of MET, TIE2 (TEK), and VEGFR2 (KDR) kinases. This profile was achieved by optimizing binding into the switch control pocket of all three kinases, inducing type II inactive conformations. Altiratinib durably inhibits MET, both wild-type and mutated forms, in vitro and in vivo. Through its balanced inhibitory potency versus MET, TIE2, and VEGFR2, Altiratinib provides an agent that inhibits three major evasive (re)vascularization and resistance pathways (HGF, ANG, and VEGF) and blocks tumor invasion and metastasis. Altiratinib exhibits properties amenable to oral administration and exhibits substantial blood-brain barrier penetration, an attribute of significance for eventual treatment of brain cancers and brain metastases.

KEYWORDS: Altiratinib | MET, TIE2 (TEK) and VEGFR2 (KDR) kinases inhibitor | DCC-2701 | DCC2701 | DCC 2701 | CT-D2701 | CAS [1345847-93-9] | HGF | c-MET | TIE2 | VEGFR | FTL3 | Trk | Inhibitor | Receptors

Balanced inhibitor for MET, TIE2 (TEK), and VEGFR2 (KDR) kinases

Chemical name


Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...