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Axon 3944

CAS [1818885-28-7]

MF C46H47ClN8O9S
MW 923.43

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO



ARV-825, dubbed as PROTAC (Proteolysis Targeting Chimera), is a potent and selective protein BRD4 degrader with DC50 value of <1 nM. It is a hetero-bifunctional molecule consisting of two high-affinity binding ligands, Thienodiazepine for BRD4 and Phthalimide for E3 ubiquitin ligase cereblon (CRBN), linked by a spacer. Bindings of two ligands to their respective receptors recruit the target protein BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. Consequently, ARV-825 suppresses more effectively c-MYC levels and downstream signaling than small-molecule BRD4 inhibitors, resulting in more effective cell proliferation inhibition and apoptosis induction in BL.

KEYWORDS: ARV-825 | BRD4 degrader | ARV825 | ARV 825 | CT-ARV825 | CAS [1818885-28-7] | Histone | BET (BRD) | Degrader | Proteins | PROTAC

Potent and selective protein BRD4 degrader

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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