AVN-944 is an orally available, uncompetitive small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme catalyzing the rate limiting step in the biosynthesis of guanine nucleotides. As IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, thus inhibition of this enzyme will result in depletion of guanine nucleotide pools, cessation of DNA synthesis, cell cycle block at the Gr(1)/S interface and interference with cell division, and induction of apoptosis. The reduction in guanine nucleotide pools will also interfere with the ability of G-coupled proteins to act as intracellular signal transducers.

KEYWORDS: AVN944 | IMPDH inhibitor | VX-944 | AVN-944 | AVN 944 | VX944 | VX 944 | CT-AVN944 | CAS [297730-17-7] | Inosine monophosphate (IMP) | IMPDH | Inhibitor | Enzymes