(R)-SKBG-1

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Axon 3928

CAS [2955634-67-8]

MF C22H26ClN3O6S
MW 495.98

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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(R)-SKBG-1

Description

(R)-SKBG-1 is a covalent RNA-binding protein NONO ligand. (R)-SKBG-1 promoted NONO accumulation in nuclear foci and stabilized NONO–RNA interactions, supporting a trapping mechanism that may prevent compensatory action of paralog proteins PSPC1 and SFPQ. Also, (R)-SKBG-1 showed IC50 values of 3.1 and 5.5 μM for depleting AR-FL and AR-V7 mRNA, respectively. The inactive enantiomer (S)-SKBG-1 is available as Axon 3929.

Keywords: (R)-SKBG-1 | Supplier | NONO ligand | (R)-SKBG1 | (R)-SKBG 1 | CAS [2955634-67-8] | Androgenic hormones | Androgen (AR) | Ligand | Receptors | RNA-binding protein NONO | RBP | non-POU domain-containing octamer binding

Covalent RNA-binding protein NONO ligand

Chemical name

(R)-4-(2-Chloroacetyl)-N-(4-methoxybenzyl)-1-(4-methoxyphenylsulfonyl)piperazine-2-carboxamide

Parent CAS No.

[2955634-67-8]

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5 mg €160.00 In Stock
25 mg €640.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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