(R)-SKBG-1 is a covalent RNA-binding protein NONO ligand. (R)-SKBG-1 promoted NONO accumulation in nuclear foci and stabilized NONO–RNA interactions, supporting a trapping mechanism that may prevent compensatory action of paralog proteins PSPC1 and SFPQ. Also, (R)-SKBG-1 showed IC50 values of 3.1 and 5.5 μM for depleting AR-FL and AR-V7 mRNA, respectively. The inactive enantiomer (S)-SKBG-1 is available as Axon 3929.

Keywords: (R)-SKBG-1 | Supplier | NONO ligand | (R)-SKBG1 | (R)-SKBG 1 | CAS [2955634-67-8] | Androgenic hormones | Androgen (AR) | Ligand | Receptors | RNA-binding protein NONO | RBP | non-POU domain-containing octamer binding