GSK046 - iBET-BD2

Based on 12 reference(s) in Google Scholar 8 10 12

Axon 3921

CAS [2474876-09-8]

MF C23H27FN2O4
MW 414.47

  • Purity: 98%
  • Optical purity: 99%
  • Soluble in DMSO



GSK046 is a domain-selective and orally active inhibitor of BET with immunomodulatory activity, targeting specifically BDII (Bromodomain II) with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.

KEYWORDS: GSK046 | Supplier | BET inhibitor | iBET-BD2 | GSK-046 | GSK 046 | iBETBD2 | iBET BD2 | CT-GSK046 | CAS [2474876-09-8] | Histone | BET (BRD) | Inhibitor | Proteins

Domain-selective and orally active inhibitor of BET with immunomodulatory activity

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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