GSK1070916 - NMI-900

Based on 54 reference(s) in Google Scholar 8 10 54

Axon 3920

CAS [942918-07-2]

MF C30H33N7O
MW 507.63

  • Purity: 99%
  • Soluble in DMSO



GSK1070916 is a potent, selective and ATP competitive inhibitor of Aurora B and C kinases with Ki values of 0.38 and 1.5 nM, respectively, and is highly selective over Aurora A (Ki = 490 nM). Its inhibition of Aurora B and C is time-dependent, with an enzyme-inhibitor dissociation half-life of >480 min and 270 min respectively, a unique feature compared to other Aurora B Kinase inhibitors under clinical development. It is selective over other kinase targets with an exception of of FLT1, TIE2, SIK, FLT4, and FGFR1 (with IC50 values of 42, 59, 70, 74, and 78 nM, respectively).

KEYWORDS: GSK1070916 | Supplier | Aurora B and C kinase inhibitor | NMI-900 | GSK-1070916 | GSK 1070916 | NMI900 | NMI 900 | CAS [942918-07-2] | Non Selective (LIM;p53;TPX2) | Aurora | Inhibitor | Enzymes

Size Unit Price Stock
5 mg €110.00 In Stock
25 mg €360.00 In Stock
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Size Unit Price Stock
2 x 5 mg €180.00 In Stock
2 x 25 mg €560.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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