GSK3368715 is a first-in-class, orally active, potent and selective, SAM-Noncompetive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs) with IC50 in lower nM; alters exon usage and shows anti-tumor efficacy in multiple cancer models; synergizes with the PRMT5 inhibitor GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.

KEYWORDS: GSK3368715 hydrochloride | Supplier | PRMT inhibitor | GSK715 hydrochloride | EPZ019997 hydrochloride | GSK-3368715 | GSK 3368715 | GSK-715 | GSK 715 | EPZ-019997 | EPZ 019997 | CT-GSK715 | CAS [2227587-25-7] | [1629013-22-4] | Non Selective (Arginine sites proteins) | PRMT | Inhibitor | Enzymes