IACS-13909 hydrochloride

Based on 1 reference(s) in Google Scholar 12 14 1

Axon 3903

CAS [N.A.]

MF C17H18Cl2N6.HCl
MW 413.73

  • Purity: 99%
  • Soluble in water and DMSO

IACS-13909 hydrochloride


IACS-13909 is a potent and specific allosteric inhibitor of SHP2, suppressing the signaling of RTK/MAPK pathway. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to Osimertinib, IACS-13909 administered as a single agent or in combination with Osimertinib potently reduces tumor cell proliferation in vitro and in vivo, which provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC.

KEYWORDS: IACS-13909 hydrochloride | Supplier | SHP2 inhibitor | IACS13909 | IACS 13909 | CT-IACS909 | CAS [N.A.] | [2160546-07-4] | Non Selective (Tyrosine specific phosphomonoesters) | SHP | Inhibitor | Enzymes

Potent and specific allosteric inhibitor of SHP2

Chemical name

1-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine hydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...