Based on 4 reference(s) in Google Scholar 8 10 4

Axon 3894

CAS [1627696-51-8]

MW 309.30

  • Purity: 99%
  • Optical purity: 99%
  • Soluble in DMSO



LY-3177833 is a orally available, potent and selective inhibitor of CDC7 (Cell Division Cycle 7-related Protein Kinase), inhibiting CDC7/DBF4 I and pMCM2 (S53) with IC50 values of 3.3 nM and 290 nM, respectively. The inhibition profoundly impacts chromosome dynamics. Broad antitumor activity was associated with robust dose/exposure-dependent in vivo target inhibition in mouse xenograft models. In addition, the preclinical profile of the compound was different from nonselective CDC7 inhibitors and cytotoxic agents, which supports its clinical development with a continuous dosing regimen.

KEYWORDS: LY-3177833 | Supplier | CDC7 inhibitor | LY3177833 | LY 3177833 | CT-LY3177 | CAS [1627696-51-8] | DNA-RNA | CDC7 | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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