Based on 11 reference(s) in Google Scholar 8 10 11

Axon 3876

CAS [1338542-14-5]

MF C23H24N2O2S
MW 392.51

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO



TOPK (T–lymphokine-activated killer cell–originated protein kinase), an enzyme that is heavily and frequently transactivated in various cancer tissues, including lung and triple-negative breast cancers, plays a vital role in the mitosis of cancer cells. Optically pure OTS-964 is a TOPK small molecular inhibitor, binding to the enzyme potently and selectively with IC50 at lower nM. The inhibition causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. The drug delivered in a liposomal formulation effectively caused complete regression of transplanted tumors without any detectable side effects in mice. The salt OTS964 hydrochloride (Axon 4097) is also available.

KEYWORDS: OTS-964 | Supplier | TOPK inhibitor | OTS964 | OTS 964 | CT-OTS964 | CAS [1338542-14-5] | Non Selective (Serine peptide bonds) | TOPK | CDK | Inhibitor | Enzymes

TOPK (T–lymphokine-activated killer cell–originated protein kinase) inhibitor

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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