PCI-27483

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3875

CAS [871266-63-6]

MF C26H24N6O9S
MW 596.57

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

PCI-27483

Description

PCI-27483 is a potent and selective small-molecule inhibitor of activated factor VII (factor VIIa). FVII, a serine protease, becomes activated (FVIIa) upon binding with TF forming the FVIIa/TF complex, which induces intracellular signaling pathways by activating protease activated receptor 2 (PAR-2). Upon subcutaneous administration, PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex, which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways, thereby inhibiting tumor cell proliferation, angiogenesis, and metastasis of TF-overexpressing tumor cells. In addition, this agent inhibits both the extrinsic and intrinsic coagulation cascades, preventing blood clot formation. TF, a blood protein overexpressed on the cell surface of a variety of tumor cell types, may correlate with poor prognosis; PAR-2 (also known as thrombin receptor-like 1) is a G protein-coupled receptor (GPCR) and a protease-activated receptor.

KEYWORDS: PCI-27483 | Supplier | FVIIa/tissue factor inhibitor | PCI27483 | PCI 27483 | CT-PCI274 | CAS [871266-63-6] | Non Selective (Serine peptide bonds) | FVIIa | Inhibitor | Enzymes

PCI-27483 is a potent and selective small-molecule inhibitor of activated factor VII (factor VIIa)

Chemical name

(S)-2-(2-(5-(5-Carbamimidoyl-1H-benzo[d]imidazol-2-yl)-2',6-dihydroxy-5'-sulfamoylbiphenyl-3-yl)acetamido)succinic acid

Source information

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Parent CAS No.

[871266-63-6]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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