Based on 22 reference(s) in Google Scholar 8 10 22

Axon 3869

CAS [1242156-23-5]

MF C35H35FN6O3
MW 606.69

  • Purity: 99%
  • Soluble in DMSO



RN486 is a selective, and reversible inhibitor of Bruton's tyrosine kinase (BTK), binding to the enzyme potently and competitively with an in vitro IC50 of 4.0 nM (enzymatic assay), and 0.3 nM (FRET binding assay). Highly selective over almost all other kinases including Syk and JAK, two validated RA (Rheumatoid Arthritis) targets. It exhibits an excellent pharmacokinetic profile, and displayed strong functional as well as disease-related activities by inhibiting immune responses mediated by two important immunoreceptors, BCR and FcR, in both human cells and rodents, producing dose dependent efficacy in both CIA and AIA, with evidence for substantial efficacy in combination with low-dose methotrexate.

KEYWORDS: RN486 | Supplier | BTK inhibitor | RN-486 | RN 486 | CT-RN486 | CAS [1242156-23-5] | B-Cell transformation | BTK | Inhibitor | Enzymes

Selective and reversible inhibitor of Bruton's tyrosine kinase (BTK)

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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