RMC-4550 hydrochloride

Based on 19 reference(s) in Google Scholar 8 10 19

Axon 3868

CAS [N.A.]

MF C21H27Cl2N4O2.HCl
MW 473.82

  • Purity: 99%
  • Optical purity: 99% d.e.
  • Soluble in DMSO

RMC-4550 hydrochloride


RMC-4550 is a potent, selective and orally available small molecule allosteric inhibitor of SHP2, acting by stabilizing the SHP2 protein in an inactive conformation that is unable to transmit cell growth signals. It inhibits purified, activated full length human SHP2 with an IC50 of 1.6 nM, and has cellular IC50 of 39 nM in PC9 cells with a pERK readout. RMC-4550 has no detectable inhibitory activity up to 10 µM against the catalytic domain of SHP2, a panel of 14 additional protein phosphatases, and a panel of 468 protein kinases. RMC-4450 as a single agent was found to attenuate signal transduction through the RAS-MAP kinase cascade, reduce tumor growth and cause tumor cell death in preclinical xenograft studies of human tumors carrying select mutations in the RAS-MAP kinase pathway.

KEYWORDS: RMC-4550 hydrochloride | Supplier | SHP2 inhibitor | RMC4550 | RMC 4550 | CT-RMC4550 | CAS [N.A.] | [2172651-73-7] | Non Selective (Tyrosine specific phosphomonoesters) | SHP | Inhibitor | Enzymes

Potent, selective and orally available small molecule allosteric inhibitor of SHP2

Chemical name

(3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl)methanol hydrochloride

Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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