SCH772984 hydrochloride

Based on 199 reference(s) in Google Scholar 8 10 199

Axon 3867

CAS [N.A.]

MF C33H33N9O2.HCl
MW 624.14

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in 0.1N HCl(aq) and DMSO

SCH772984 hydrochloride


Extracellular signal regulated kinase (ERK) is a pivotal enzyme in the pathway downstream of Ras, Raf, and MEK, acting as a central link between multiple signaling pathways. SCH772984 is a potent, specific and ATP competitive inhibitor of ERK1 and ERK2 with IC50s at low nMs. It inhibits phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phospho-RSK) in a dose-dependent manner, and also inhibits phosphorylation of residues in the activation loop of ERK itself. More importantly, it effectively inhibits MAPK signaling and cell proliferation in BRAF or MEK inhibitor-resistant models as well as in tumor cells resistant to concurrent treatment with BRAF and MEK inhibitors.

KEYWORDS: SCH772984 hydrochloride | Supplier | ERK1 and ERK2 inhibitor | SCH-772984 | SCH 772984 | SCH984 | SCH 984 | CT-SCH772 | CAS [N.A.] | [942183-80-4] | MAPK | ERK | Inhibitor | Enzymes

Potent, specific and ATP competitive inhibitor of ERK1 and ERK2

Chemical name

(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide hydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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